Book Hotels in South Sanford, ME

Cabins, apartments, houseboats! We offer comfortable & private vacation rentals

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Check prices for these dates

Tonight
Apr 13 - Apr 14
Tomorrow
Apr 14 - Apr 15
This weekend
Apr 17 - Apr 19
Next weekend
Apr 24 - Apr 26

Filter by

Guest rating
Guest rating
Star rating
Payment type
Payment type
Property type
Property type
Neighborhood
Neighborhood
Traveler experience
Traveler experience
Popular locations
Popular locations
Meal plans available
Meal plans available
Property amenities
Property amenities
Accessibility
Accessibility

Top South Sanford hotels

Hampton Inn & Suites Portsmouth Downtown

Hampton Inn & Suites Portsmouth Downtown

3 out of 5
23 Portwalk Pl Portsmouth NH
Fully refundableReserve now, pay when you stay
$126 nightly
The price is $136 total per night from Apr 26 to Apr 27
$136 total
Apr 26 - Apr 27
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and valet parking. ...
Rooms were clean. Beds were reasonably comfortable, though mattresses seemed older. Great breakfast. Loved the valet parking. Very pet friendly.

Reviewed on Apr 12, 2026

Opens in a new windowHampton Inn & Suites Portsmouth Downtown
Cliff House Maine

Cliff House Maine

4.5 out of 5
591 Shore Road Cape Neddick ME
$427 nightly
The price is $465 total per night from Apr 30 to May 1
$465 total
Apr 30 - May 1
Total with taxes and fees
A full-service spa, 2 restaurants, and an indoor pool are all featured at this smoke-free resort. Traveling on business? Take advantage of the business center, ...
The property is amazing and the staff were polite and very attentive. It’s a negative for me that I couldn’t take my 8 year old in the outdoor pool, but I’m sure if i wasn’t there with a child I’d appreciate a kid-free zone. The indoor pool was pretty filthy, with some wrappers and things floating ...

Reviewed on Mar 31, 2026

Opens in a new windowCliff House Maine
The Hotel Portsmouth

The Hotel Portsmouth

3 out of 5
40 Court St. Portsmouth NH
Fully refundableReserve now, pay when you stay
$179 nightly
The price is $194 total per night from Apr 21 to Apr 22
$194 total
Apr 21 - Apr 22
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the 4 ...
We really enjoyed our stay. The room size worked great for a family of 4. We were able to walk to dinner each night. Breakfast was nice but not a large selection if you’re picky. I would only criticize the daily room service. Some days we got no service and some days one bed was made out of 3. It ...

Reviewed on Apr 11, 2026

Opens in a new windowThe Hotel Portsmouth
Anchorage by the Sea

Anchorage by the Sea

3 out of 5
125 Shore Road Ogunquit ME
$202 nightly
The price is $220 total per night from May 3 to May 4
$220 total
May 3 - May 4
Total with taxes and fees
This smoke-free hotel features 2 hot tubs, an indoor pool, and a restaurant. Traveling on business? Take advantage of the free WiFi in public areas and onsite ...
The room was very spacious and clean. The pool and hot tub were nice as was the sauna. Great location to walk into town !

Reviewed on Apr 12, 2026

Opens in a new windowAnchorage by the Sea
Holiday Inn Express Wells-Ogunquit-Kennebunk by IHG

Holiday Inn Express Wells-Ogunquit-Kennebunk by IHG

3 out of 5
28 Mile Road Wells ME
Fully refundable
$94 nightly
The price is $102 total per night from Apr 16 to Apr 17
$102 total
Apr 16 - Apr 17
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
The breakfast was varied and fresh. The coffee grinding machine was a nice extra. The staff were friendly. The room was spotless. There was plenty of parking. Overall, it was a great place t stay.

Reviewed on Apr 11, 2026

Opens in a new windowHoliday Inn Express Wells-Ogunquit-Kennebunk by IHG
Anchorage Inn and Resort

Anchorage Inn and Resort

3 out of 5
265 Long Beach Avenue York Beach ME
$99 nightly
The price is $108 total per night from Apr 14 to Apr 15
$108 total
Apr 14 - Apr 15
Total with taxes and fees
This hotel features 2 indoor pools, an outdoor pool, and a restaurant. Enjoy the gym and perks like free self parking and free WiFi. Enjoy the hot tub and unwind ...
Well-maintained and clean room with all the extras.

Reviewed on Apr 12, 2026

Opens in a new windowAnchorage Inn and Resort
Hampton Inn Portsmouth Central

Hampton Inn Portsmouth Central

2.5 out of 5
131 DOW AVENUE Portsmouth NH
Fully refundableReserve now, pay when you stay
$92 nightly
The price is $100 total per night from Apr 30 to May 1
$100 total
Apr 30 - May 1
Total with taxes and fees
This hotel features an indoor pool and a gym. Business travelers can take advantage of the free WiFi in public areas. Enjoy the hot tub and free perks like buffet ...
Hot tub was perfect and breakfast staff were great

Reviewed on Apr 10, 2026

Opens in a new windowHampton Inn Portsmouth Central
Hilton Garden Inn Portsmouth Downtown

Hilton Garden Inn Portsmouth Downtown

3 out of 5
100 High St Portsmouth NH
Fully refundableReserve now, pay when you stay
$111 nightly
The price is $120 total per night from Apr 20 to Apr 21
$120 total
Apr 20 - Apr 21
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and ...
Room was clean and comfortable. Enjoyed the stay. I am a Hilton Honors member, im not sure that was noted on my stay

Reviewed on Apr 13, 2026

Opens in a new windowHilton Garden Inn Portsmouth Downtown
Sheraton Portsmouth Harborside Hotel

Sheraton Portsmouth Harborside Hotel

3.5 out of 5
250 Market St Portsmouth NH
Fully refundableReserve now, pay when you stay
$147 nightly
The price is $160 total per night from Apr 19 to Apr 20
$160 total
Apr 19 - Apr 20
Total with taxes and fees
This hotel features an indoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
The rooms were clean and the staff were attentive.

Reviewed on Apr 3, 2026

Opens in a new windowSheraton Portsmouth Harborside Hotel
Don't see what you're looking for?
See all available properties in South Sanford
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

What are the top kid-friendly hotels in South Sanford?
Family getaways are where treasured memories are made, but traveling with youngsters can be demanding. These kid-friendly South Sanford hotels come with perks designed to keep travelers of all ages comfortable and happy: You're well catered for at Huttopia Southern Maine. It comes with a swimming pool, a playground and a commitment to making families feel at home. Otherwise, spend your nights in South Sanford at Quality Inn. Make the most of complimentary breakfast, pet-friendly facilities and more here.
Where can I find cheap hotels in South Sanford?
At Travelocity you'll find really nice hotels in South Sanford at great prices. We source incredible prices with our trusted partners, so you have a tempting selection of cheap hotels to choose from. If you can be flexible on dates and location, consider staying at a hotel near South Sanford rather than in South Sanford. We may find you even better rates, too.
How do I find the best South Sanford hotel deals?
Simple! On Travelocity, look through the fantastic offers we've already found in South Sanford then use our filters to find a great deal that's perfect for you. Enter your travel dates, select the number of rooms you need, and we'll do the rest. You can get great discounts on flights and car hire, too, when you bundle.
How much does it cost to stay in a hotel in South Sanford?
The cheapest hotel in South Sanford is $100. This price was available within the past 7 days, for stays with a check-in date within the next year. Of course, the price you pay depends on your dates of travel, the length of your stay, and the hotel's location. Prices and availability are subject to change. Additional terms apply.
How many hotels are in South Sanford?
There are 3,829 hotels in South Sanford on Travelocity.
What are the best hotels in South Sanford?
South Sanford has so many great hotels to choose from at Travelocity — and it's so easy to find the perfect one. Just choose one of our popular pre-selected hotels with great reviews, or you can refine your search to build your ideal stay. Simply filter hotels based on price or star rating, or select properties with a pool, a hot tub, or a range of other amenities and pick the best place to stay in South Sanford for you!
When is the best time to visit South Sanford?
If you want the joy of a fun-filled trip in peak season, visit South Sanford during January, June and August. If you'd prefer the peace of off-season, book a stay during quieter months, such as April, September and October.
When is the cheapest time to stay in South Sanford?
Based on historic data is usually the cheapest month to visit South Sanford. However, we have incredible deals all year round, so we're confident you'll find a room in your budget whenever you choose to travel.
Are there any great family-friendly hotels in South Sanford?
There are multiple hotels in South Sanford that will please the whole family. Do you need adjoining rooms, babysitting services or a swimming pool? We've got you covered. Use our family filter to narrow your search down and use guest reviews to help you pick the perfect place for your next family trip to South Sanford. We have plenty of kid-friendly hotels in South Sanford to choose from on Travelocity!
Why book a hotel in South Sanford through Travelocity?
Because we have the top hotels in South Sanford! We want to help you travel more and worry less. That's why we've put the most amazing hotel, car rental, and flight deals in one place. When you search for hotels with us, you know you're getting fantastic prices with no hidden fees and free cancellation on most properties up to 24 hours before your stay. If you become a Travelocity member, you also get exclusive member discounts. Sign up today!
How do I cancel my hotel booking in South Sanford on Travelocity?
Canceling your booking with Travelocity is easy. Sign into your account and select My Trips. Here, you will see your cancellation options. We offer free cancellation on many properties.

Recent South Sanford hotel reviews by fellow wanderers

Hilton Garden Inn Portsmouth Downtown

Hilton Garden Inn Portsmouth Downtown

5 out of 5
Posted 4 hours ago
Travelocity Verified Review
"Room was clean and comfortable. Enjoyed the stay. I am a Hilton Honors member, im not sure that was noted on my stay"
A verified traveler stayed at Hilton Garden Inn Portsmouth Downtown
Hilton Garden Inn Portsmouth Downtown

Explore More Ways to Travel with Travelocity